Plaque Research Today is a free monthly online journal that collates and summarizes the latest research about Plaque, including details on dentistry, brushing, oral hygiene, mouthwash.

Oral health status, salivary factors and microbial analysis in patients with active gastro-oesophageal reflux disease.

Filipi K, Halackova Z, Filipi V

Department of Conservative Dentistry, St Anna's Faculty Hospital, and Faculty of Medicine, Masaryk University, Brno, Czech Republic. 44343@mail.muni.cz

Published 19 August 2011 in Int Dent J, 61(4): 231-7.
Full-text of this article is available online (may require subscription).

Articles on Plaque published 15 August 2011:

Detection of neuritic plaques in Alzheimer's disease mouse model.   J Vis Exp.

Alzheimer's disease (AD) is the most common neurodegenerative disorder leading to dementia. Neuritic plaque formation is one of the pathological hallmarks of Alzheimer's disease. The central component of neuritic plaques is a small filamentous protein called amyloid β protein (Aβ)(1), which is derived from sequential proteolytic cleavage of the beta-amyloid precursor protein (APP) by β-secretase and γ-secretase. The amyloid hypothesis entails that Aγ-containing plaques as the underlying ... [Abstract] [Full-text]

Dynamics of polymerization shed light on the mechanisms that lead to multiple amyloid structures of the prion protein.   Biochim Biophys Acta, 1814(10): 1305-17.

It is generally accepted that spongiform encephalopathies result from the aggregation into amyloid of a ubiquitous protein, the so-called prion protein. As a consequence, the dynamics of amyloid formation should explain the characteristics of the prion diseases: infectivity as well as sporadic and genetic occurrence, long incubation time, species barriers and strain specificities. The success of this amyloid hypothesis is due to the good qualitative agreement of this hypothesis with the ... [Abstract] [Full-text]

Articles on Plaque published 20 July 2011:

Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles.   J Neuropathol Exp Neurol, 70(8): 653-61.

The relevance of cerebral amyloid angiopathy (CAA) to the pathogenesis of Alzheimer disease (AD) and dementia in general emphasizes the importance of developing novel targeting approaches for detecting and treating cerebrovascular amyloid (CVA) deposits. We developed a nanoparticle-based technology that uses a monoclonal antibody against fibrillar human amyloid-β42 that is surface coated onto a functionalized phospholipid monolayer. We demonstrate that this conjugated nanoparticle binds to CVA ... [Abstract] [Full-text]

Articles on Plaque published 1 July 2011:

Novel quinoxaline derivatives for in vivo imaging of β-amyloid plaques in the brain.   Bioorg Med Chem Lett, 21(14): 4193-6.

In a search for new probes to detect β-amyloid plaques in the brain of patients with Alzheimer's disease (AD), we have synthesized and evaluated a series of quinoxaline derivatives containing a '6+6-6' ring system. These quinoxaline derivatives showed excellent affinity for Aβ(1-42) aggregates with K(i) values ranging from 2.6 to 10.7nM. Autoradiography with sections of brain tissue from an animal model of AD mice (APP/PS1) and AD patients revealed that [(125)I]5 labeled β-amyloid plaques ... [Abstract] [Full-text]

Articles on Plaque published 27 June 2011:

Telomere shortening reduces Alzheimer's disease amyloid pathology in mice.   Brain, 134: 2044-56.

Alzheimer's disease is a neurodegenerative disorder of the elderly and advancing age is the major risk factor for Alzheimer's disease development. Telomere shortening represents one of the molecular causes of ageing that limits the proliferative capacity of cells, including neural stem cells. Studies on telomere lengths in patients with Alzheimer's disease have revealed contrary results and the functional role of telomere shortening on brain ageing and Alzheimer's disease is not known. Here, we ... [Abstract] [Full-text]

Contribution of host genotype to the composition of health-associated supragingival and subgingival microbiomes.   J Clin Periodontol, 38(6): 517-24.

[Abstract] [Full-text]

Articles on Plaque published 24 June 2011:

Synthesis and evaluation of benzofuran-2-yl(phenyl)methanone derivatives as ligands for β-amyloid plaques.   Bioorg Med Chem, 19(13): 4148-53.

A series of benzofuran-2-yl(phenyl)methanone derivatives were synthesized and evaluated as novel probes for β-amyloid plaques. These derivatives were produced by a Rap-Stoermer condensation reaction. Compounds with a N,N-dimethylamino group displayed high affinity for Aβ(1-42) aggregates with K(i) values in the nanomolar range. Autoradiography with brain sections of AD model mice (APP/PS1) revealed that a radioiodinated probe, [(125)I]10, labeled β-amyloid plaques selectively and displayed ... [Abstract] [Full-text]

MPC-polymer reduces adherence and biofilm formation by oral bacteria.   J Dent Res, 90(7): 900-5.

Oral biofilms such as dental plaque cause dental caries and periodontitis, as well as aspiration pneumonia and infectious endocarditis by translocation. Hence, the suppression of oral biofilm formation is an issue of considerable importance. Mechanical removal, disinfectants, inhibition of polysaccharide formation, and artificial sugar have been used for the reduction of oral biofilm. From the viewpoint of the inhibition of bacterial adherence, we investigated whether aqueous biocompatible ... [Abstract] [Full-text]

© 2004-2011 Plaque Research Today. All Rights Reserved.